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Oocyte donation

Certain couples cannot have a child either naturally or through medical support in procreation. In vitro fertilisation has sometimes failed several times. In some cases, the woman produces only a very few eggs (oocytes), if any at all (premature ovarian insufficiency). Sometimes, MAP attempts fail, suggesting that oocyte quality has been altered.

This may be explained by a genetic disease, medical treatment (chemotherapy, radiotherapy, etc.) and even surgery (ovarian cyst or endometriosis surgery), but the cause is not usually found.

In such situations, couples may benefit from oocyte donation.

Oocyte donation may also benefit couples at risk of transmitting a genetic disease likely to be transmitted via the egg. In particular, if pre-implant testing is not possible from a technical point of view or if it has failed, oocytes may be donated to prevent the risk of transmitting disease.

Shortage of oocyte donors in France explains the relatively long time it takes to receive a donation (18 months to 5 years depending on the region and the recipient’s ethnicity). Donated embryos must always be transferred before the recipient’s 43rd birthday.

Donor

By French law, donation is anonymous and free of charge. Any adult female under 37, in good health, with or without children, may donate. The whole procedure is 100% covered. Moreover, childless women may have their oocytes stored for use later, if they wish.

It is vital that during its course, the donor meets different healthcare professionals: a gynaecologist, psychologist, geneticist and reproduction biologist. The consultations will assess the donor’s state of health by exploring her personal and family history and explain what oocyte donation is, what it entails and rare side effects. An ultrasound examination to assess ovarian reserve and biological examinations (assessments of hormones, serologies and caryotype (gene test)) will also be conducted. If the patient is eligible, a 100% claim for cover will be filed.

The donor must undergo ovarian stimulation over a period of about 10-12 days. It is similar to that undergone by patients during IVF. It will end with an oocyte puncture under local or general anaesthetic. The oocytes obtained will be sent to the laboratory to either be frozen by means of vitrification for donation later, or for in vitro fertilisation with the receiving patient’s spouse’s sperm (previously frozen).

Receiving couple

It is vital that during its course, the couple meets different healthcare professionals: a gynaecologist, psychologist, geneticist and reproduction biologist. The consultations will assess the couple’s state of health by exploring their personal and family history and explain what oocyte donation is and what it entails. Examinations will be conducted to assess whether the recipient would benefit from oocyte donation (blood test, pelvic ultrasound and if necessary, a consultation with a specialist, depending on personal history). The patient’s physical features will be noted to assess pairing with the donor (skin colour, eye colour, hair colour). An appointment at the Regional Court must be organised to obtain consent.

The uterus of the patient receiving the oocytes must be prepared before embryos from IVF between the donor’s oocyte and the receiving patient’s spouse’s sperm are placed. Thus, oestrogen hormone treatment per os (or orally), or via a patch or vaginally, will be administered so that the mucous membrane of the uterus proliferates. A single follow-up ultrasound and blood test (doses of hormones) are usually sufficient to ensure that the endometrium is the correct thickness to receive the embryo. Treatment with ovules or progesterone injections will then be necessary in addition to the oestrogen for 2 to 5 days for embryo transfer. In the event of pregnancy, hormone treatment must be continued for several weeks.

BOOK YOUR CONSULTATION

Public consultations (sector 1, without exceeding fees): contact the appointment office of Antoine Béclère Hospital: 01 41 07 95 95

BOOK YOUR PRIVATE CONSULTATION

Private consultations (sector 2, with overruns): contact Ms. Céline Delattre at 01.45.37.40.53. or celine.delattre@aphp.fr